High Blood Pressure Articles and Abstracts

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High Blood Pressure Journal Articles



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Fluorometric assay of histamine in blood using high pressure liquid chromatography and reaction of the effluent with ortho-phthalaldehyde
Laureri, C. F., E. Gaetani, et al. (1984), Farmaco Prat 39(1): 29-32.

Folk beliefs about high blood pressure in Hispanic immigrants
Ailinger, R. L. (1988), West J Nurs Res 10(5): 629-36.

Follow up of young people with high casual blood pressure
Cosenzi, A., A. Sacerdote, et al. (1996), J Hum Hypertens 10 Suppl 3: S71-5.
Abstract: High blood pressure (BP), often borderline hypertension, can be also found in adolescents. In these subjects the haemodynamic pattern, high cardiac output and normal vascular resistance, differs from that of older hypertensives. Although the risk for hypertension is higher in this group than in the general population, only a minority of them will develop sustained hypertension later in life. They can therefore be viewed as an enriched pool of future hypertensives but not as true prehypertensives. The aim of this longitudinal study was to analyse the relation between casual BP measured in high school students and in the same subjects 3 years later. In 1990, an extensive study on BP was carried out in 1062 high school students aged 18 years. Sitting BP, heart rate, weight, and body mass index (BMI) were measured in each subject. After 3 years, the 50 subjects with the highest BP level recorded in 1990 were recalled. Forty-five subjects (90%, 30 males and 15 females) agreed to undergo a second examination. They were seen as outpatients in the Hypertension Centre of our institute. BP was measured with a mercury sphygmomanometer after a 10 min rest three times in 5 min. Systolic and diastolic BP were significantly reduced after 3 years (137 +/- 13 vs 132 +/- 10 P = 0.002; 92 +/- 4 vs 85 +/- 6 P = 0.0001, mm Hg). By means of a multiple regression test, including parameters recorded in 1990, systolic blood pressure (SBP) (R = 0.53 Slg F = 0.0002) and diastolic blood pressure (DBP) (R = 0.60 Slg F = 0.0001) were shown as the main determinants of SBP, while DBP was related only to previous BMI (R = 0.37 Slg F = 0.01). The reduction of both SBP and DBP after 3 years could be explained either by a true, spontaneous decrease of BP or as a consequence of different environmental conditions during the second examination (more prolonged resting time, repeated measurements). However, data of this study demonstrate that casual SBP and DBP are the main determinants of future SBP, thus confirming the prognostic value of casual BP measurement in young people. Moreover, our data emphasises the role of BMI as the main determinant of future high DBP.

For the patient. Community health workers help to reduce high blood pressure
Levine, D. M., L. R. Bone, et al. (2003), Ethn Dis 13(3): 403.

For the patient. High blood pressure: the silent killer
Ashaye, M. O. and W. H. Giles (2003), Ethn Dis 13(4): 546-7.

Forty three-years-old woman with high blood pressure, respiratory tract infection, asthenia, adynamia, hyporexia, and icteric tint
Bierzwinsky-Sneider, G., R. Zacarias, et al. (2004), Gac Med Mex 140(3): 335-40.

Frequency of high blood pressure in hallucinatory psychoses, (Atypic tuberculosis with reference to Selye's research).
Hyvert, M. and H. Fagard (1951), Ann Med Psychol (Paris) 109(5): 608-11.

Fruit and vegetable consumption is inversely associated with blood pressure in a Mediterranean population with a high vegetable-fat intake: the Seguimiento Universidad de Navarra (SUN) Study
Alonso, A., C. de la Fuente, et al. (2004), Br J Nutr 92(2): 311-9.
Abstract: There is evidence that a diet rich in fruit and vegetables reduces blood pressure (BP). Characteristically, the Mediterranean diet is rich in plant-derived foods and also in fat, but studies conducted in Mediterranean countries to relate diet to BP are scarce. We studied the association between fruit and vegetable consumption and BP in a cross-sectional analysis of 4393 participants in the Seguimiento Universidad de Navarra (SUN) Study, an ongoing dynamic cohort study in Spain. Diet was measured using a food-frequency questionnaire previously validated in Spain. Fat represented more than 37 % total energy intake. Subjects were considered to have undiagnosed hypertension if they reported systolic BP > or = 140 mmHg or diastolic BP > or = 90 mmHg, and not a medical diagnosis of hypertension. The adjusted prevalence odds ratio of undiagnosed hypertension (upper v. lowest quintile) was 0.58 (95 % CI 0.36, 0.91; P for trend 0.01) for vegetable consumption and 0.68 (95 % CI 0.43, 1.09; P for trend 0.10) for fruit consumption. Comparing those in the highest quintile of both fruit and vegetable consumption with those in the lowest quintile of both food groups, the prevalence odds ratio was 0.23 (95 % CI 0.10, 0.55; P = 0.001), after adjusting for risk factors for hypertension and other dietary exposures. In a Mediterranean population with an elevated fat consumption, a high fruit and vegetable intake is inversely associated with BP levels.

Functional cardiovascular status in patients with high blood pressure and coronary heart disease in a remote period of uranium intoxication
Treti'iakov, S. V., L. A. Shpagina, et al. (2002), Med Tr Prom Ekol(2): 6-11.
Abstract: High blood pressure and coronary heart disease in far-off period of chronic uranium intoxication result in re-modelling of left ventricle with predominant concentric re-modelling. Lower myocardial mass of left ventricle and more marked changes in diastolic function occurred in the main group if compared to the reference one having no contact with occupational hazards.

Functional pathology in high blood pressure.
Vogralik, V. G. (1950), Klin Med (Mosk) 28(7): 27-35.

Further learnings from the European Working Party on High Blood Pressure in the Elderly (EWPHE) study: focus on systolic hypertension
O'Malley, K., J. P. Cox, et al. (1991), Cardiovasc Drugs Ther 4 Suppl 6: 1249-51.
Abstract: Event rates in relation to the number of elderly hypertensives treated were calculated from randomized analysis data from the 840 patients who completed the European Working Party on High Blood Pressure in the Elderly (EWPHE) trial. In all, the actively treated group had 29 fewer cardiovascular events per 1000 patient years. Putting this another way, treating 34 patients for 1 year would prevent one cardiovascular event. Moreover, as there were 14 fewer cardiovascular deaths and 11 fewer nonfatal strokes per 1000 patient years in the actively treated groups, we calculated that treating 71 or 91 elderly patients for 1 year would prevent one cardiovascular death or nonfatal stroke, respectively. Because of the higher baseline incidence of cardiovascular events in this study, there were greater gains in terms of absolute reductions in mortality and morbidity in treated elderly hypertensive patients than in younger patients in similar studies. Of the 840 patients who participated in the trial, 247 had systolic blood pressure greater than or equal to 160 mmHg and diastolic blood pressure less than or equal to 95 mmHg. In this group, blood pressure was reduced by 13/8 mmHg after 3 years in those randomized to active treatment compared to placebo. While patient numbers were insufficient to draw firm conclusions, their outcome on treatment was similar to that for patients on active treatment in the overall study. These results high-light the need for a rigorous assessment of the value of treating isolated systolic hypertension in the elderly.

Future management of high blood pressure
Johnston, C. I. (1996), J Cardiovasc Pharmacol 27 Suppl 3: S55-60.
Abstract: Both population (mass) strategies and targeted strategies for the management of high blood pressure are necessary. However, it has yet to be proven that reducing blood pressure by lifestyle changes in the population will confer the same cardiovascular benefit that results from lowering blood pressure by drugs. It is important to identify and correct those factors in hypertensive patients, such as obesity, smoking, elevated lipids, and diabetes, that confer high risk for an adverse cardiovascular event. It is now recognized that cardiovascular risk involves not only diet and lifestyle effects but that the structural and functional abnormalities resulting from high blood pressure are of great importance. There is a need to develop and validate new noninvasive methods for quantitating these structural and functional changes, together with assessment of endothelial dysfunction, hormonal profiling, and identification of susceptible genes so that high risk patients with hypertension can be selected for drug therapy. In the future, selection of an appropriate antihypertensive drug for an individual patient should also involve consideration of risk factors, structural changes, hormonal status, and genetic consideration. Central inhibition of peripheral sympathetic action by imidazoline receptor agonists, such as moxonidine, may lead to reversal of these structural and functional abnormalities without adverse effects on the central nervous system.

Genesis and surgical therapy of essential and released high blood pressure.
Gagel, O. (1950), Munch Med Wochenschr 92(7-8): 253-60.

Genetic and sociocultural components of high blood pressure
Ward, R. H. (1983), Am J Phys Anthropol 62(1): 91-105.
Abstract: The cardiovascular diseases exert widely differing contributions to the total burden of mortality and morbidity in extant human populations. To a large extent these differences are a reflection of the variable distribution of specific antecedent risk factors. For one such risk factor, blood pressure, there is considerable variability in its distribution between different ethnic groups, especially between traditional and nontraditional societies. Intensive epidemiological studies in Western societies, together with a number of cross-cultural comparisons, suggest that the major determinants of high blood pressure are likely to be a constellation of sociocultural factors, with genetic determination being limited to the interaction between genotype and environment. Studies of populations in sociocultural transition offer an unique opportunity to identify the relative influence of specific sociocultural factors on the rate of change of blood pressure. In addition, when the study of such populations is placed in a quasi-experimental context, genetic-environmental interactions may also be detected. This strategy is illustrated by a study of the changing blood pressure distribution in Tokelauan migrants. Such an approach requires the initial definition of a response variable which measures change in blood pressure as a consequence of migration. The response variable, which identifies the relative influence of concomitants such as weight, age, and obesity, can then be subjected to genetic analysis. In the Tokelau case, blood pressure response tends to be positive in migrants but negative in nonmigrants. Further statistical analysis indicates that there is a small proportion of high responders in both populations and that these cluster in families in the migrant population. However, estimates of the transmission parameter suggest that sociocultural transmission, rather than Mendelian segregation, is responsible. To date there is little evidence that genetic-environmental interactions have had any impact on the development of hypertension in this migrant population.

Genetic disposition as the 1st step in the development of high blood pressure
Weber, P. C. and B. Scherer (1980), Verh Dtsch Ges Inn Med 86: 285-94.

Genetic variation at the angiotensinogen locus in relation to high blood pressure and myocardial infarction: the ECTIM Study
Tiret, L., S. Ricard, et al. (1995), J Hypertens 13(3): 311-7.
Abstract: OBJECTIVES: To study the association between polymorphisms of the angiotensinogen (AGT) gene and blood pressure in population-based samples, and to determine whether genetic variation at the AGT locus is involved in the susceptibility to myocardial infarction. METHODS: The study population comprised 630 cases who survived a myocardial infarction, recruited from the World Health Organization Monitoring Cardiovascular Diseases registers in Belfast, Lille, Strasbourg and Toulouse, and 741 controls drawn from the corresponding populations. The AGT polymorphisms investigated were T174M and M235T. High blood pressure was defined as diastolic blood pressure > 100 mmHg or the use of antihypertensive medication, or both. RESULTS: In the controls the mean +/- SEM frequency of the M174 allele was 0.116 +/- 0.008, and that of the T235 allele was 0.401 +/- 0.013. In the whole population blood pressure levels and prevalence of high blood pressure did not vary according to T174M and M235T genotypes. However, obesity appeared as a crucial factor influencing the relationship between high blood pressure and T174M. In subjects with body mass index < 26 kg/m2 there was a 2.4-fold increase of the prevalence of high blood pressure in carriers of the M174 allele compared with in homozygotes for the T174 allele, whereas no association was detected in subjects with body mass index > 26 kg/m2. The association between high blood pressure and M235T was not significant in either group. The T174M and M235T genotype distributions did not differ between survivors of myocardial infarction and controls. CONCLUSIONS: These data suggest that the AGT gene could be involved in the predisposition to high blood pressure in non-overweight, but not in overweight men, possibly reflecting genetically different types of hypertension. No significant impact of the AGT locus in the risk of non-fatal myocardial infarction was detected.

Geographical and socioeconomic distribution of high blood pressure and borderline high blood pressure in a Swedish rural county
Haglund, B. J. (1985), Scand J Soc Med 13(2): 53-66.
Abstract: This report on "high" blood pressure (HBP) and "borderline high" blood pressure (BHBP) is based on a cross-sectional study in a rural Swedish county. The study was initiated in the Spring of 1977, selecting 7986 individuals aged 25-75 years, in 5-year intervals, in the 16 municipalities of Skaraborg County. A combination of health examination and a survey using polling of the population by interview was used. The blood pressure values that are presented are based on a casual measurement taken after a 5-minute rest period. The limits of HBP and BHBP correspond to the Swedish standard limits. Only a few researchers in Sweden have focused on the correlation between socioeconomic factors and hypertension. Moreover, few examinations have been made internationally concerning the correlation between socioeconomic factors and borderline hypertension. There was a significant variation in mean values of high blood pressure when comparing socioeconomic groups and comparing occupations. These differences associated with educational level were more pronounced for women than for men. Workers, especially men and persons with less formal education, had the highest mean blood pressure. Significant differences between socioeconomic groups existed even after adjustment for age, sex, weight index, smoking and treatment of hypertension. The socioeconomic differences constitute the most plausible explanation of differences seen between municipalities. "Borderline high" blood pressure was more prevalent than "high" blood pressure. Socioeconomic differences were greater within the borderline high blood pressure group than in the high blood pressure group. i.e., the differences between workers and civil servants were somewhat greater in the borderline high blood pressure group. Since there are socioeconomic differences, it might be possible to concentrate preventive activities in local communities on risk groups.

Ginseng and high blood pressure
Siegel, R. K. (1980), Jama 243(1): 32.

Glomerular hyperfiltration, high renin, and low- extracellular volume in high blood pressure
Harrap, S. B., A. D. Cumming, et al. (2000), Hypertension 35(4): 952-7.
Abstract: Abnormal renovascular resistance and glomerular filtration rate are characteristic of established hypertension and may also be involved in its pathogenesis. To determine renal and body fluid correlates of the predisposition to high blood pressure, we examined 100 healthy young adults with high or low blood pressure. Within each group, half had parents with high blood pressures, and half had parents with low blood pressures. Renal function and hemodynamics, body fluid volumes, and relevant hormones and genotypes were measured. Subjects with high personal and parental blood pressures had the highest levels of glomerular filtration rate (P<0.02) and plasma active renin concentration and low levels of exchangeable sodium and plasma volume (P<0.02). High glomerular filtration rate was not associated with differences in urinary kallikrein or prostaglandins. Polymorphisms of the renin, angiotensin-converting enzyme, and angiotensinogen genes were not associated with differences in glomerular filtration rate or renin. Subjects with high personal, but low parental, blood pressures had low exchangeable sodium and plasma volumes (P<0.02) but normal glomerular filtration rates. In this population, extracellular volume depletion and high renin are correlates of high blood pressure in early adulthood, and glomerular hyperfiltration is a feature of those who also have familial predisposition to high blood pressure.

Glucose effectiveness is strongly related to left ventricular mass in subjects with stage I hypertension or high-normal blood pressure
Stiefel, P., M. L. Miranda, et al. (2004), Am J Hypertens 17(2): 146-53.
Abstract: BACKGROUND: Evidence suggests that "glucose effectiveness," (SG) or the effect of glucose per se to enhance net glucose disposal, may be at least as important as the insulin sensitivity index (SI) in the assessment of glucose tolerance. Our objective was to study the relationship of SG and SI parameters to left ventricular mass in a group of untreated, nondiabetic, and nonobese subjects recently diagnosed with stage I or high-normal blood pressure (BP). METHODS: In this sample of subjects, among whom the expected prevalence of insulin resistance is low, we assessed SG and SI parameters using the intravenous glucose tolerance test and minimal model analysis. We also measured left ventricular mass (LVM) index and diastolic function by echocardiography. RESULTS: We observed a strong relationship between SG and LVM index (r = -0.61, P <.0001). Patients with left ventricular hypertrophy (LVH) had lower SG than those without LVH (0.1114 +/- 0.04 v 0.2088 +/- 0.08 x 10(-1). min(-1), P <.001). In contrast, patients below the lowest quartile of the SG parameter distribution had higher LVM index (126.4 +/- 23.1 v 94.8 +/- 22.3 g/m(2), P <.001) and also had higher prevalence of LVH than the other patients (P <.0001). The SI related only to diastolic dysfunction, suggesting that SG may be an earlier marker of LVH than SI in hypertension. CONCLUSION: In this sample of nonobese and glucose-tolerant subjects with an early stage of hypertension, SG but not SI was related to LVM.

Glucose intolerance during diuretic therapy in elderly hypertensive patients. A second report from the European Working Party on high blood pressure in the elderly (EWPHE)
Amery, A., W. Birkenhager, et al. (1986), Postgrad Med J 62(732): 919-24.
Abstract: Five hundred and seven elderly hypertensive patients were followed for 1 year, 371 for 2 years and 270 for 3 years in a double-blind, randomized, controlled trial in which they received either placebo or 25-50 mg hydrochlorothiazide and 50-100 mg of triamterene daily. One third of the active treatment group also received 250 mg to 2 g methyldopa daily. After 1 year the active treatment group had an average increase in fasting blood sugar of 2.5 mg/dl compared with an average fall of 1.4 mg/dl in the placebo group (P = 0.01). The increase in blood sugar 1 hour and 2 hours after 50 g oral glucose tended to be greater in the actively treated group but these increases did not achieve statistical significance. The effects of diuretic treatment were established after one year and did not increase further over the next 2 years. Overall there was an increase in fasting blood sugar of 5 mg/dl in the active treatment group which occurred mainly in the first year. The hyperglycaemic effect of diuretics appeared to be partly or wholly related to potassium loss since, in both groups, impairment of glucose tolerance was most marked in those in whom serum potassium decreased. The measures of blood sugar were also positively related to systolic pressure before and after treatment.

Guidelines for a dental office high blood pressure screening program
Abbey, L. M. and B. Hargrave (1974), Va Dent J 51(4): 52-7.

Guidelines for diagnosis, treatment and follow-up of high blood pressure
Paran, E. (1995), Harefuah 128(11): 723-7.

Guidelines for measurement of blood pressure, follow-up, and lifestyle counselling. Canadian Coalition for High Blood Pressure Prevention and Control
Abbott, D., N. Campbell, et al. (1994), Can J Public Health 85 Suppl 2: S29-43.
Abstract: As part of the Coalition's mandate to promote the prevention and control of high blood pressure in Canada, an interdisciplinary Workgroup was established to review and update the existing standards (1987) for blood pressure measurement and referral guidelines. The intent was to prepare a scientifically based document which contained practical guidelines for the measurement of blood pressure and criteria for follow-up, and one which promoted the concept of cardiovascular health in the assessment and interpretation of blood pressure readings. These guidelines were primarily developed to assist primary health care providers and/or clinicians to assess, monitor, counsel, refer, and develop treatment plans for adults-at-risk for high blood pressure or those with the confirmed diagnosis of hypertension. Readers are referred to The Canadian Hypertension Society Consensus Conference series (Canadian Medical Association Journal 1993) for specific guidelines on the evaluation, diagnosis, and treatment of hypertension. The document is divided into three sections: 1. Measurement of blood pressure 2. Criteria for follow-up 3. Guidelines for lifestyle counselling Each section cites the references used in developing the guidelines and where relevant, identifies other resources which can be used in clinical practice.

Guidelines for the treatment of arterial hypertension in diabetes mellitus. The consensus recommendations of the German League for the Fight against High Blood Pressure, Inc., the German Diabetes Society and the Society for Nephrology
Schafers, R. F., P. Lutkes, et al. (1999), Dtsch Med Wochenschr 124(45): 1356-72.

Guidelines on high blood pressure in pregnancy give new classifications of disease
Rollins, G. (2000), Rep Med Guidel Outcomes Res 11(24): 5-7.

Haemodynamic changes associated with obesity and high blood pressure in rats with ventromedial hypothalamic lesions
Reisin, E., D. H. Suarez, et al. (1980), Clin Sci (Lond) 59 Suppl 6: 397s-399s.
Abstract: 1. The haemodynamic and plasma volume changes associated with obesity and high blood pressure were studied in nine male rats with electrolytic ventromedial hypothalamic lesions and their paired sham-operated controls. Body weight and arterial pressure were greater in the rats with ventromedial hypothalamic lesions (565 +/- 16 vs 462 +/- 14 g, P < 0.001; 128 +/- 3 vs 118 +/- 3 mmHg, P < 0.05, respectively). Cardiac output was slightly elevated, and that portion of cardiac output distributed to the kidneys was reduced (P < 0.001). Plasma volume was contracted in the rats with ventromedial hypothalamic lesions (21.0 +/- 0.1 vs 2.8 +/- 0.1 ml/100 g, P < 0.001). 2. The haemodynamic characteristics of rats in which obesity and mild hypertension have been induced by electrolytic ventromedial hypothalamic lesion are similar to mild obesity essential hypertension in men.

Health and exercise: effects of exercise on high blood pressure
Ikeda, M., H. Nanri, et al. (1993), J Uoeh 15(3): 227-36.
Abstract: Many factors, such as genetic, psychological, environmental, and socioeconomical factors, influence the health of individuals. Recently behavioral risks which cause preventable chronic diseases or premature death have been increasing. These risk factors are mainly due to living habits, such as over-eating, less exercise and psychological stress. Physical activity or fitness is reported to be inversely associated with morbidity and mortality from chronic diseases, such as cardiovascular diseases diabetes mellitus, cancer and so on. Hypertension has also been reported to be associated with low physical fitness in cross-sectional studies. We have so far reported a significant blood pressure reduction in mild hypertensive patients who completed mild intensity exercise training in well controlled studies. Exercise seemed to modify the multiple factors that might participate in raising and maintaining high blood pressure. The mechanisms of lowering blood pressure by exercise training are mainly due to a depletion of blood volume or the reduction of both cardiac output and the sympathetic tone. They were supported by the evidence of increased levels of prostaglandin E, dopamine, taurine, and decreased levels of plasma norepinephrine and endogenous ouavain-like substance. In this article, we have reviewed the physiological and biochemical roles of exercise, the effects of exercise on high blood pressure, and the hypotensive mechanism of mild aerobic exercise hypertensive patients.

Health awareness and treatment compliance of high blood pressure among women in a peri-urban colony of Chandigarh, India
Thakur, K., P. Malhotra, et al. (1999), J Indian Med Assoc 97(6): 217-9.
Abstract: Health awareness is a central issue in the control of hypertension. In a cross-sectional survey among 1727 women of > 30 years, 2 blood pressure recordings were done in 1686 cases. The prevalence of hypertension was found to be 13.1% (221 out of 1686 cases). A random sub sample of 72 hypertensive women above 30 years of age from a peri-urban colony of Chandigarh was selected to find out health awareness and treatment compliance of hypertension. Sixty-three (87.5%) of the selected women were aware of their high blood pressure. However, only 12 women (16.7%) who were on treatment had achieved control of blood pressure (< 140/90 mm Hg). Main reasons for discontinuing the treatment were ignorance about the need of regular treatment (33.3%), high cost of medicines (19.44%) and non-availability of a family member who can go with the patient to hospital (9.72%). Twenty-six (36.1%) hypertensive women did not know the importance of weight reduction for controlling high blood pressure. Twenty-three (31.9%) hypertensive women were currently smoking. A comprehensive health education approach involving health care professionals, patients and general population should be launched to improve the care of hypertensives in the community.

Health education in patients with high blood pressure
Pintiliescu, M. (1981), Viata Med Rev Inf Prof Stiint Cadrelor Medii Sanit 29(2): 41-2.

Health survey concerning high blood pressure in the community of Alvsby 1977
Huhtasaari, F. and U. Schaufele (1979), Lakartidningen 76(40): 3419-21.

Heart and blood pressure adaptations in Wistar rats fed with different high-fat diets for 18 months
Aguila, M. B. and C. A. Mandarim-de-Lacerda (2003), Nutrition 19(4): 347-52.
Abstract: OBJECTIVE: We investigated the effect of long-term administration of four different high-fat diets on systolic blood pressure (SBP), body and heart biometry, and left ventricular myocyte nuclei number (Nlvm). METHODS: Twenty-four Wistar rats were assigned to one of four groups from weaning to age 18 mo. The rats were fed experimental diets containing soybean oil (S group), canola oil (CA group), lard and egg yolk (LE group), and canola oil plus lard and egg yolk (CA + LE group). N(lvm) was measured with the disector method in isotropic uniform random sections of the left ventricular myocardium. RESULTS: There were no significant differences across experimental groups in morphometric indices. SBP was higher in the LE group at all ages and lower in the 18-mo CA group. The myocardium structure analysis separated the animals in three major categories: the CA and LE groups as the extreme and the S and CA + LE groups as the intermediary. In the LE group the myocardium presented more important structural changes: cardiac myocytes were enlarged and surrounded with thick collagen bundles, and some regions exhibited myocardial necrosis. CONCLUSION: Long-term intake of the CA diet was more efficient in maintaining normal N(lvm) and SBP than the S and LE diets. The CA + LE diet resulted in balanced levels of SBP and N(lvm) in rats, suggesting that canola oil reduces cardiovascular injury caused by intake of lard and egg yolk.

Heart failure in patients with high blood pressure
Mickerson, J. N. (1959), Br Heart J 21(2): 218-24.

Heart/body weight ratios for aging high and low blood pressure mice
Elias, M. F., P. K. Elias, et al. (1977), Exp Aging Res 3(3): 231-8.
Abstract: Heart weight and heart/body weight ratios were determined for stocks of mice bred from Schlager's high and low blood pressure mice. Results of an analysis in which three different age groups (means = 15, 17, and 28 months) were compared indicated a nonsignificant interaction between age and blood pressure for heart weight and between age and blood pressure for heart/body weight ratios. Heart weight and heart/body weight ratios were significantly higher for the high than for the low BP mice at all ages with one exception; heart weights did not differ between the two lines at mean age 28 months. It was concluded that high blood pressure mice do not exhibit cardiac hypertrophy in the strictest sense of a disproportionately greater increase in heart/body weight ratios across the life span than low blood pressure for this particular stock.

Help lower the mercury and control high blood pressure
Classe, J. G. and E. C. Marshall (1996), J Am Optom Assoc 67(5): 245-7.

High altitude and blood pressure in children
Arslan, S., N. Arslan, et al. (2003), Yale J Biol Med 76(4): 145-8.
Abstract: We aimed to evaluate the blood pressure of children who had similar demographic characteristics but lived at different altitudes. Blood pressure of the children attending primary schools in Izmir (sea level: n = 425) and Van (altitude: 1725 m, n = 291) were measured by mercurial sphygmomanometer for this study. They were similar with respect to age, sex, weight, height, and BMI. Mean age of the children was 10.51 +/- 0.87 years (range: 9 to 12 years), and 358 (50 percent) of them were female. Mean systolic blood pressure was significantly higher in the children living in Van than in the children living in Izmir (104.72 +/- 11.2 vs. 97.96 +/- 25.5 mmHg, respectively, p <.001). Similarly mean diastolic blood pressure was significantly higher in the children living in Van than in the children living in Izmir (63.98 +/- 9.3 vs. 59.91 +/- 10.0 mmHg, respectively, p <.001). When blood pressure was evaluated with regard to height percentile, the number of children with a blood pressure over 90 percentile were 19 (4.5 percent) and 48 (16.5 percent) for systolic blood pressure, and 25 (5.9 percent) and 37 (12.7 percent) for diastolic blood pressure among the children living in Izmir and Van, respectively (p <.001). Systolic and diastolic blood pressures were found to increase in parallel to the increase in body mass index in children living in Van (r = 0.358, p <.001 and r = 0.235, p <.001, respectively). However, blood pressures were not correlated to body mass index in children living in Izmir. A difference of 1700 m in altitude was associated with higher systolic and diastolic blood pressure levels in children with similar demographic characteristics, and at this altitude, body mass index and blood pressure showed a positive correlation.

High barium levels in public drinking water and its association with elevated blood pressure
Brenniman, G. R., W. H. Kojola, et al. (1981), Arch Environ Health 36(1): 28-32.
Abstract: A maximum contaminant level for barium in drinking water has been set at 1. mg/L. This study examines for the first time, whether there are significant differences in mean blood pressure levels between a high and a low barium community. A total of approximately 2,400 Illinois residents in West Dundee, with a mean barium drinking water level of 7.3 mmg/L, and in McHenry, with a mean barium level of 0.1 mg/L, were studied. All other drinking water constituents were nearly identical between the two communities, with the major difference being the level of barium ingested. No significant differences (P greater than.05) were found in blood pressures between the high and low barium communities. Adjustment for duration of exposure, home water softeners, and high blood pressure medication did not alter the findings. The data from this study suggest that elevated levels of barium in drinking water do not significantly elevate blood pressure levels in adult males or females. It is recommended that the drinking water standard of 1. mg/L be re-examined for other possible health effects.

High blood pressure (hypertension)
Woods, A. (2002), Nursing 32(4): 54-5.

High blood pressure
Cushing, M., Jr. (1973), Ann Intern Med 78(6): 982.

High blood pressure
Lovibond, J. L. (1950), Cyprus Med J 3(6-7): 365-9; Greek transl, 370-5.


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